Essential role for a novel population of binucleated mammary epithelial cells in lactation Rios, AC, Fu, NY, Jamieson, PR, Pal, B, Whitehead, L, Nicholas, Kevin, Lindeman, GJ and Visvader, JE 2016, Essential role for a novel population of binucleated mammary epithelial cells in lactation, Nature Communications, vol. 7, pp. 1-12, doi: 10.1038/ncomms11400. Attached Files Name Description MIMEType Size Downloads Title Essential role for a novel population of binucleated mammary epithelial cells in lactation Author(s) Rios, AC Fu, NY Jamieson, PR Pal, B Whitehead, L Nicholas, Kevin orcid.org/0000-0003-0366-0031 Lindeman, GJ Visvader, JE Journal name Nature Communications Volume number 7 Article ID 11400 Start page 1 End page 12 Total pages 12 Publisher Nature Place of publication London, Eng Publication date 2016-04 ISSN 2041-1723 Summary The mammary gland represents a unique tissue to study organogenesis as it predominantly develops in the post-natal animal and undergoes dramatic morphogenetic changes during puberty and the reproductive cycle. The physiological function of the mammary gland is to produce milk to sustain the newborn. Here we view the lactating gland through three-dimensional confocal imaging of intact tissue. We observed that the majority of secretory alveolar cells are binucleated. These cells first arise in very late pregnancy due to failure of cytokinesis and are larger than mononucleated cells. Augmented expression of Aurora kinase-A and Polo-like kinase-1 at the lactogenic switch likely mediates the formation of binucleated cells. Our findings demonstrate an important physiological role for polyploid mammary epithelial cells in lactation, and based on their presence in five different species, suggest that binucleated cells evolved to maximize milk production and promote the survival of offspring across all mammalian species. Language eng DOI 10.1038/ncomms11400 HERDC Research category C1.1 Refereed article in a scholarly journal Free to Read? Yes Persistent URL http://hdl.handle.net/10536/DRO/DU:30158930 Document type: Journal Article Collections: Institute for Frontier Materials Open Access Collection GTP Research Related Links Link Description Link to full-text (open access)   Connect to Elements publication management system Go to link with your DU access privileges     Unless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved. Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au. Versions Version Filter Type Mon, 22 Nov 2021, 07:33:24 EST Mon, 22 Nov 2021, 15:15:09 EST Mon, 22 Nov 2021, 15:21:48 EST Fri, 13 May 2022, 06:02:36 EST Wed, 29 Jun 2022, 16:30:10 EST Wed, 29 Jun 2022, 16:41:27 EST Wed, 29 Jun 2022, 16:48:01 EST Filtered Full Citation counts:   Cited 0 times in TR Web of Science Cited 52 times in Scopus Search Google Scholar Access Statistics: 9 Abstract Views, 0 File Downloads  -  Detailed Statistics Created: Mon, 22 Nov 2021, 07:33:24 EST