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Sphingolipid imbalance and inflammatory effects induced by uremic toxins in heart and kidney cells are reversed by dihydroceramide desaturase 1 inhibition

Savira, Feby, Magaye, R, Scullino, CV, Flynn, BL, Pitson, SM, Anderson, D, Creek, DJ, Hua, Y, Xiong, X, Huang, L, Liew, D, Reid, C, Kaye, D, Kompa, AR and Wang, BH 2021, Sphingolipid imbalance and inflammatory effects induced by uremic toxins in heart and kidney cells are reversed by dihydroceramide desaturase 1 inhibition, Toxicology Letters, vol. 350, pp. 133-142, doi: 10.1016/j.toxlet.2021.07.012.

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Title Sphingolipid imbalance and inflammatory effects induced by uremic toxins in heart and kidney cells are reversed by dihydroceramide desaturase 1 inhibition
Author(s) Savira, Feby
Magaye, R
Scullino, CV
Flynn, BL
Pitson, SM
Anderson, D
Creek, DJ
Hua, Y
Xiong, X
Huang, L
Liew, D
Reid, C
Kaye, D
Kompa, AR
Wang, BH
Journal name Toxicology Letters
Volume number 350
Start page 133
End page 142
Total pages 10
Publisher Elsevier
Place of publication Amsterdam, The Netherlands
Publication date 2021-10-10
ISSN 0378-4274
1879-3169
Keyword(s) ACCUMULATION
CARDIAC FIBROSIS
CARDIORENAL SYNDROME
CERAMIDE
Desl inhibitor
Dihydroceramide desaturase 1
HYPERTROPHY
INDOXYL SULFATE
INDUCTION
Life Sciences & Biomedicine
NATRIURETIC PEPTIDES
NF-KAPPA-B
OXIDATIVE STRESS
Science & Technology
Sphingolipids
Toxicology
Uremic toxins
Des1 inhibitor
Language eng
DOI 10.1016/j.toxlet.2021.07.012
Field of Research 0502 Environmental Science and Management
1115 Pharmacology and Pharmaceutical Sciences
HERDC Research category C1 Refereed article in a scholarly journal
Persistent URL http://hdl.handle.net/10536/DRO/DU:30159102

Document type: Journal Article
Collections: Faculty of Health
School of Health and Social Development
Institute for Health Transformation
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Created: Tue, 23 Nov 2021, 07:11:57 EST

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