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Attenuating PI3K/Akt- mTOR pathway reduces dihydrosphingosine 1 phosphate mediated collagen synthesis and hypertrophy in primary cardiac cells

Magaye, RR, Savira, Feby, Hua, Y, Xiong, X, Huang, L, Reid, C, Flynn, BL, Kaye, D, Liew, D and Wang, BH 2021, Attenuating PI3K/Akt- mTOR pathway reduces dihydrosphingosine 1 phosphate mediated collagen synthesis and hypertrophy in primary cardiac cells, International Journal of Biochemistry and Cell Biology, vol. 134, pp. 1-16, doi: 10.1016/j.biocel.2021.105952.

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Title Attenuating PI3K/Akt- mTOR pathway reduces dihydrosphingosine 1 phosphate mediated collagen synthesis and hypertrophy in primary cardiac cells
Author(s) Magaye, RR
Savira, Feby
Hua, Y
Xiong, X
Huang, L
Reid, C
Flynn, BL
Kaye, D
Liew, D
Wang, BH
Journal name International Journal of Biochemistry and Cell Biology
Volume number 134
Article ID 105952
Start page 1
End page 16
Total pages 16
Publisher Elsevier
Place of publication Amsterdam, The Netherlands
Publication date 2021-05
ISSN 1357-2725
1878-5875
Keyword(s) Akt
Biochemistry & Molecular Biology
Cardiac remodelling
Cell Biology
Dihydrosphingosine 1 phosphate
FIBROBLASTS
Fibrosis
GATA4
GLYCOGEN-SYNTHASE KINASE-3-BETA
HEART
Hypertrophy
INHIBITION
Life Sciences & Biomedicine
MICE
mTOR
PHOSPHORYLATION
PI3K
Protein kinase B
RECEPTOR STIMULATION
Ribosomal protein S6
Science & Technology
Sphingolipid
SPHINGOSINE-1-PHOSPHATE
TRANSCRIPTION
Protein kinase B/Akt
Language eng
DOI 10.1016/j.biocel.2021.105952
Field of Research 0601 Biochemistry and Cell Biology
1101 Medical Biochemistry and Metabolomics
1116 Medical Physiology
HERDC Research category C1 Refereed article in a scholarly journal
Persistent URL http://hdl.handle.net/10536/DRO/DU:30159104

Document type: Journal Article
Collections: Faculty of Health
School of Health and Social Development
Institute for Health Transformation
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Citation counts: TR Web of Science Citation Count  Cited 5 times in TR Web of Science
Scopus Citation Count Cited 6 times in Scopus Google Scholar Search Google Scholar
Access Statistics: 11 Abstract Views, 0 File Downloads  -  Detailed Statistics
Created: Tue, 23 Nov 2021, 07:12:16 EST

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