Strong association between serum Vitamin D and Vaspin Levels, AIP, VAI and liver enzymes in NAFLD patients Izadi, A, Aliasghari, F, Gargari, BP and Ebrahimi, Sara 2020, Strong association between serum Vitamin D and Vaspin Levels, AIP, VAI and liver enzymes in NAFLD patients, International Journal for Vitamin and Nutrition Research, vol. 90, no. 1-2, pp. 59-66, doi: 10.1024/0300-9831/a000443. Title Strong association between serum Vitamin D and Vaspin Levels, AIP, VAI and liver enzymes in NAFLD patients Author(s) Izadi, A Aliasghari, F Gargari, BP Ebrahimi, Sara orcid.org/0000-0001-8439-5684 Journal name International Journal for Vitamin and Nutrition Research Volume number 90 Issue number 1-2 Start page 59 End page 66 Total pages 8 Publisher Hogrefe Place of publication Boston, Mass. Publication date 2020-01 ISSN 0300-9831 1664-2821 Keyword(s) Vitamin D NAFLD Adipokines Lipid profiles Summary Some studies indicated poor vitamin D level in NAFLD which is independently correlated with severity of steatosis. Low 25(OH) D3 levels are associated with an impaired lipid profile. Impaired levels and function of vaspin and omentin, which are adipokines, have been demonstrated in NAFLD patients. This study determined the relationship between vitamin D and serum liver enzymes, ultrasound findings, some adipokines, atherogenic index of plasma (AIP) and visceral adiposity index (VAI) in patients with NAFLD in a cross-sectional study. This study was a cross-sectional study in eighty-three NAFLD patients (57 males and 26 females). Plasma levels of omentin-1e-1, vaspin were measured. Anthropometric indices metabolic status was assessed. Visceral adiposity index and atherogenic index of plasma were calculated according to suggested formula. Anthropometric indices, lipid profiles, liver enzymes as well as abdominal ultrasonography and the status of vitamin D were assessed. The results showed that aspartate aminotransferase (AST) (44.22 ± 8.5 IU/L vs. 40.19 ± 8.75 IU/L, p-value = 0.039) AIP (0.767 ± 0.142 vs. 0.6417 ± 0.139, p < 0.001) and VAI (9.28 ± 3.25 vs. 7.048 ± 2.415, p = 0.001) were significantly higher in patients with vitamin D deficiency compared to those with vitamin D sufficiency. The positive correlations between Vaspin levels and vitamin D were found to be remarkably significant in both males and females (r = 0.437; P = 0.004; P < 0.001, r =-0.709, respectively. In both males and females serum vitamin D concentrations were negatively associated with AIP. Partial correlations controlling for age and sex showed that vitamin D is significantly and inversely associated with AIP, VAI, AST, and ALT. Additionally, vitamin D levels correlated directly with vaspin. Language eng. DOI 10.1024/0300-9831/a000443 Field of Research 1111 Nutrition and Dietetics HERDC Research category C1 Refereed article in a scholarly journal Persistent URL http://hdl.handle.net/10536/DRO/DU:30159633 Document type: Journal Article Collections: Faculty of Health School of Exercise and Nutrition Sciences Related Links Link Description Connect to published version Go to link with your DU access privileges   Connect to Elements publication management system Go to link with your DU access privileges     Unless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved. Versions Version Filter Type Mon, 29 Nov 2021, 12:41:49 EST Mon, 29 Nov 2021, 15:06:19 EST Wed, 15 Dec 2021, 05:06:01 EST Thu, 28 Apr 2022, 15:22:45 EST Thu, 28 Apr 2022, 16:53:28 EST Thu, 28 Apr 2022, 16:55:28 EST Filtered Full Citation counts:   Cited 0 times in TR Web of Science Cited 6 times in Scopus Search Google Scholar Access Statistics: 10 Abstract Views  -  Detailed Statistics Created: Mon, 29 Nov 2021, 12:41:49 EST