Unhealthy lifestyle, genetics and risk of cardiovascular disease and mortality in 76,958 individuals from the UK biobank cohort study Livingstone, Katherine, Abbott, Gavin, Ward, J and Bowe, Steve 2021, Unhealthy lifestyle, genetics and risk of cardiovascular disease and mortality in 76,958 individuals from the UK biobank cohort study, Nutrients, vol. 13, no. 12, pp. 1-10, doi: 10.3390/nu13124283. Attached Files Name Description MIMEType Size Downloads Title Unhealthy lifestyle, genetics and risk of cardiovascular disease and mortality in 76,958 individuals from the UK biobank cohort study Author(s) Livingstone, Katherine orcid.org/0000-0002-9682-7541 Abbott, Gavin orcid.org/0000-0003-4014-0705 Ward, J Bowe, Steve orcid.org/0000-0003-3813-842X Journal name Nutrients Volume number 13 Issue number 12 Article ID 4283 Start page 1 End page 10 Total pages 10 Publisher MDPI Place of publication Basel, Switzerland Publication date 2021-11 ISSN 2072-6643 2072-6643 Keyword(s) BEHAVIOR BURDEN cardiovascular disease DIET QUALITY genetic risk HEALTH healthy lifestyle Life Sciences & Biomedicine mortality myocardial infarction Nutrition & Dietetics Science & Technology SCORE stroke Summary To examine associations of unhealthy lifestyle and genetics with risk of all-cause mortality, cardiovascular disease (CVD) mortality, myocardial infarction (MI) and stroke. We used data on 76,958 adults from the UK Biobank prospective cohort study. Favourable lifestyle included no overweight/obesity, not smoking, physical activity, not sedentary, healthy diet and adequate sleep. A Polygenic Risk Score (PRS) was derived using 300 CVD-related single nucleotide polymorphisms. Cox proportional hazard ratios (HR) were used to model effects of lifestyle and PRS on risk of CVD and all-cause mortality, stroke and MI. New CVD (n = 364) and all-cause (n = 2408) deaths, and stroke (n = 748) and MI (n = 1140) events were observed during a 7.8 year mean follow-up. An unfavourable lifestyle (0–1 healthy behaviours) was associated with higher risk of all-cause mortality (HR: 2.06; 95% CI: 1.73, 2.45), CVD mortality (HR: 2.48; 95% CI: 1.64, 3.76), MI (HR: 2.12; 95% CI: 1.65, 2.72) and stroke (HR:1.74; 95% CI: 1.25, 2.43) compared to a favourable lifestyle (≥4 healthy behaviours). PRS was associated with MI (HR: 1.35; 95% CI: 1.27, 1.43). There was evidence of a lifestyle-genetics interaction for stroke (p = 0.017). Unfavourable lifestyle behaviours predicted higher risk of all-cause mortality, CVD mortality, MI and stroke, independent of genetic risk. Language eng DOI 10.3390/nu13124283 Indigenous content off Field of Research 0908 Food Sciences 1111 Nutrition and Dietetics HERDC Research category C1 Refereed article in a scholarly journal Free to Read? Yes Persistent URL http://hdl.handle.net/10536/DRO/DU:30160382 Document type: Journal Article Collections: Faculty of Health Institute for Physical Activity and Nutrition Open Access Collection Related Links Link Description Link to full-text (open access)   Connect to Elements publication management system Go to link with your DU access privileges     Unless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved. Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au. Versions Version Filter Type Fri, 31 Dec 2021, 13:51:03 EST Fri, 31 Dec 2021, 14:50:29 EST Sat, 15 Jan 2022, 01:31:06 EST Tue, 18 Jan 2022, 16:41:22 EST Tue, 08 Feb 2022, 16:15:39 EST Tue, 08 Feb 2022, 16:19:30 EST Thu, 10 Feb 2022, 08:16:34 EST Thu, 10 Feb 2022, 08:34:27 EST Filtered Full Citation counts:   Cited 0 times in TR Web of Science Cited 0 times in Scopus Search Google Scholar Access Statistics: 31 Abstract Views, 0 File Downloads  -  Detailed Statistics Created: Fri, 31 Dec 2021, 13:51:03 EST