Recent advances in the inhibition of the il-4 cytokine pathway for the treatment of allergen-induced asthma Massey, Oliver and Suphioglu, Cenk 2021, Recent advances in the inhibition of the il-4 cytokine pathway for the treatment of allergen-induced asthma, International Journal of Molecular Sciences, vol. 22, no. 24, pp. 1-10, doi: 10.3390/ijms222413655. Attached Files Name Description MIMEType Size Downloads Title Recent advances in the inhibition of the il-4 cytokine pathway for the treatment of allergen-induced asthma Author(s) Massey, Oliver Suphioglu, Cenk Journal name International Journal of Molecular Sciences Volume number 22 Issue number 24 Article ID 13655 Start page 1 End page 10 Total pages 10 Publisher MDPI Place of publication Basel, Switzerland Publication date 2021 ISSN 1661-6596 1422-0067 Keyword(s) ACTIVATION Biochemistry & Molecular Biology Chemistry Chemistry, Multidisciplinary DOUBLE-BLIND DUPILUMAB EFFICACY EXPRESSION immunoglobulin E (IgE) immunotherapy interleukin 13 (IL-13) interleukin 4 (IL-4) LEBRIKIZUMAB Life Sciences & Biomedicine MONOCLONAL-ANTIBODY peptide therapeutics Physical Sciences PROLIFERATION SAFETY Science & Technology STAT6 Summary The IL-4 and IL-13 cytokine pathways play integral roles in stimulating IgE inflammation, with the IL-4 cytokine being a major cytokine in the etiology of thunderstorm asthma, atopic dermatitis, and allergic rhinitis. The increasing prevalence of thunderstorm asthma in the younger population and the lessening efficacy of corticosteroids and other anti-inflammatories has created a need for more effective pharmaceuticals. This review summarizes the IL-4 and IL-13 pathways while highlighting and discussing the current pathway inhibitors aimed at treating thunderstorm asthma and atopic dermatitis, as well as the potential efficacy of peptide therapeutics in this field. Language eng DOI 10.3390/ijms222413655 Field of Research 0399 Other Chemical Sciences 0604 Genetics 0699 Other Biological Sciences HERDC Research category C1 Refereed article in a scholarly journal Free to Read? Yes Persistent URL http://hdl.handle.net/10536/DRO/DU:30160975 Document type: Journal Article Collections: Faculty of Science, Engineering and Built Environment School of Life and Environmental Sciences Open Access Collection Related Links Link Description Link to full-text (Open access) Go to link with your DU access privileges   Connect to Elements publication management system Go to link with your DU access privileges     Unless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved. Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au. Versions Version Filter Type Fri, 31 Dec 2021, 15:45:27 EST Fri, 31 Dec 2021, 16:00:32 EST Fri, 31 Dec 2021, 16:06:51 EST Fri, 31 Dec 2021, 16:27:06 EST Sat, 08 Jan 2022, 01:45:16 EST Wed, 12 Jan 2022, 09:39:37 EST Thu, 20 Jan 2022, 16:38:45 EST Wed, 23 Mar 2022, 08:01:48 EST Wed, 23 Mar 2022, 15:20:10 EST Wed, 23 Mar 2022, 15:28:25 EST Filtered Full Citation counts:   Cited 1 times in TR Web of Science Cited 1 times in Scopus Search Google Scholar Access Statistics: 11 Abstract Views, 0 File Downloads  -  Detailed Statistics Created: Fri, 31 Dec 2021, 15:45:27 EST