Evolution of variable lymphocyte receptor B antibody loci in jawless vertebrates Das, S, Rast, JP, Li, J, Kadota, M, Donald, John, Kuraku, S, Hirano, M and Cooper, MD 2021, Evolution of variable lymphocyte receptor B antibody loci in jawless vertebrates, Proceedings of the National Academy of Sciences of the United States of America, vol. 118, no. 50, pp. 1-10, doi: 10.1073/pnas.2116522118. Attached Files Name Description MIMEType Size Downloads Title Evolution of variable lymphocyte receptor B antibody loci in jawless vertebrates Author(s) Das, S Rast, JP Li, J Kadota, M Donald, John orcid.org/0000-0001-5930-2642 Kuraku, S Hirano, M Cooper, MD Journal name Proceedings of the National Academy of Sciences of the United States of America Volume number 118 Issue number 50 Article ID e2116522118 Start page 1 End page 10 Total pages 10 Publisher National Academy of Sciences Place of publication Washington, D.C. Publication date 2021-12-14 ISSN 0027-8424 1091-6490 Keyword(s) adaptive immunity DIVERSIFICATION DNA GENES GENOME PROVIDES INSIGHTS HAGFISH IDENTIFICATION immune system evolution jawless vertebrates LAMPREY Multidisciplinary Sciences REPERTOIRE RESPONSES Science & Technology Science & Technology - Other Topics transposable elements variable lymphocyte receptor Summary Significance Jawless vertebrates, lampreys and hagfish, use three types of variable leucine-rich repeat proteins as antigen receptors: VLRB on B-like cells and VLRA or VLRC on T-like lymphocytes. In their incomplete germline status, the VLRB genes in different lamprey species uniquely possess long noncoding intervening regions, which contain different sets of transposable elements and potential donor cassettes. Phylogenetic analysis of the germline VLR genes reveals ongoing evolution over the last 250 million y. Comparative assessment of genomic sequences in two lamprey species yields a detailed map of their VLRB loci. The use of this map, together with an analysis of cassette usage in a large repertoire of expressed VLRB s, supports a fragmented Lego-like model of VLRB assembly. Language eng DOI 10.1073/pnas.2116522118 HERDC Research category C1 Refereed article in a scholarly journal Persistent URL http://hdl.handle.net/10536/DRO/DU:30161073 Document type: Journal Article Collections: Faculty of Science, Engineering and Built Environment School of Life and Environmental Sciences Related Links Link Description Connect to published version Go to link with your DU access privileges   Connect to Elements publication management system Go to link with your DU access privileges     Unless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved. Versions Version Filter Type Thu, 06 Jan 2022, 15:33:14 EST Wed, 12 Jan 2022, 14:13:35 EST Sat, 15 Jan 2022, 01:30:17 EST Wed, 19 Jan 2022, 15:48:25 EST Thu, 20 Jan 2022, 05:04:01 EST Wed, 06 Apr 2022, 10:50:41 EST Wed, 06 Apr 2022, 16:14:39 EST Wed, 06 Apr 2022, 16:51:56 EST Thu, 07 Apr 2022, 15:11:28 EST Thu, 07 Apr 2022, 15:41:45 EST Wed, 20 Apr 2022, 13:42:09 EST Filtered Full Citation counts:   Cited 0 times in TR Web of Science Cited 0 times in Scopus Search Google Scholar Access Statistics: 28 Abstract Views, 5 File Downloads  -  Detailed Statistics Created: Wed, 19 Jan 2022, 15:48:25 EST