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Evolution of variable lymphocyte receptor B antibody loci in jawless vertebrates

Das, S, Rast, JP, Li, J, Kadota, M, Donald, John, Kuraku, S, Hirano, M and Cooper, MD 2021, Evolution of variable lymphocyte receptor B antibody loci in jawless vertebrates, Proceedings of the National Academy of Sciences of the United States of America, vol. 118, no. 50, pp. 1-10, doi: 10.1073/pnas.2116522118.

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Title Evolution of variable lymphocyte receptor B antibody loci in jawless vertebrates
Author(s) Das, S
Rast, JP
Li, J
Kadota, M
Donald, JohnORCID iD for Donald, John orcid.org/0000-0001-5930-2642
Kuraku, S
Hirano, M
Cooper, MD
Journal name Proceedings of the National Academy of Sciences of the United States of America
Volume number 118
Issue number 50
Article ID e2116522118
Start page 1
End page 10
Total pages 10
Publisher National Academy of Sciences
Place of publication Washington, D.C.
Publication date 2021-12-14
ISSN 0027-8424
1091-6490
Keyword(s) adaptive immunity
DIVERSIFICATION
DNA
GENES
GENOME PROVIDES INSIGHTS
HAGFISH
IDENTIFICATION
immune system evolution
jawless vertebrates
LAMPREY
Multidisciplinary Sciences
REPERTOIRE
RESPONSES
Science & Technology
Science & Technology - Other Topics
transposable elements
variable lymphocyte receptor
Summary Significance Jawless vertebrates, lampreys and hagfish, use three types of variable leucine-rich repeat proteins as antigen receptors: VLRB on B-like cells and VLRA or VLRC on T-like lymphocytes. In their incomplete germline status, the VLRB genes in different lamprey species uniquely possess long noncoding intervening regions, which contain different sets of transposable elements and potential donor cassettes. Phylogenetic analysis of the germline VLR genes reveals ongoing evolution over the last 250 million y. Comparative assessment of genomic sequences in two lamprey species yields a detailed map of their VLRB loci. The use of this map, together with an analysis of cassette usage in a large repertoire of expressed VLRB s, supports a fragmented Lego-like model of VLRB assembly.
Language eng
DOI 10.1073/pnas.2116522118
HERDC Research category C1 Refereed article in a scholarly journal
Persistent URL http://hdl.handle.net/10536/DRO/DU:30161073

Document type: Journal Article
Collections: Faculty of Science, Engineering and Built Environment
School of Life and Environmental Sciences
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