Is there an association between non-alcoholic fatty liver disease and cognitive function? A systematic review George, Elena, Sood, Surbhi, Daly, Robin and Tan, Sze Yen 2022, Is there an association between non-alcoholic fatty liver disease and cognitive function? A systematic review, BMC Geriatrics, vol. 22, no. 1, pp. 1-19, doi: 10.1186/s12877-021-02721-w. Attached Files Name Description MIMEType Size Downloads Title Is there an association between non-alcoholic fatty liver disease and cognitive function? A systematic review Author(s) George, Elena orcid.org/0000-0002-1385-2371 Sood, Surbhi Daly, Robin orcid.org/0000-0002-9897-1598 Tan, Sze Yen orcid.org/0000-0002-9607-202X Journal name BMC Geriatrics Volume number 22 Issue number 1 Article ID ARTN 47 Start page 1 End page 19 Total pages 19 Publisher BMC Place of publication London, Eng Publication date 2022 ISSN 1471-2318 1471-2318 Keyword(s) Cirrhosis Cognition Cognitive function Cognitive impairment DEMENTIA DIET Geriatrics & Gerontology Gerontology HYPERAMMONEMIA IMPACT IMPAIRMENT Life Sciences & Biomedicine METABOLIC SYNDROME NAFLD NASH OLDER-PEOPLE RISK Science & Technology Summary Abstract Background Non-alcoholic fatty liver disease (NAFLD) is represented as the most common liver disease worldwide. NAFLD is associated with metabolic risk factors underpinned by insulin resistance, inflammation and endothelial dysfunction, leading to extrahepatic changes in central nervous diseases such as cognitive impairment, Alzheimer’s disease and dementia. The aim of the review is to explore the association between NAFLD and cognitive function. Methods Using the PRISMA guidelines, a systematic electronic literature search was conducted in four databases: MEDLINE, PsychINFO, Embase and CINAHL from inception until March 2021. Neuropsychological tests utilised within each study were grouped into relevant cognitive domains including ‘general cognition’, ‘reasoning’, ‘mental speed, attention and psychomotor speed’, ‘memory and learning’, ‘language’, ‘visuospatial perception’ and ‘ideas, abstraction, figural creations and mental flexibility’. Results Eleven observational studies that involved 7978 participants with a mean age of 51 years were included. Those with NAFLD had poor cognitive performance in three cognitive domains, including ‘general cognition’, ‘mental speed, attention and psychomotor speed’, and ‘ideas, abstraction, figural creations and mental flexibility’. Conclusion The observed results from the 11 included studies showed that NAFLD was associated with lower cognitive performance across several domains. However, studies conducted to date are limited to observational designs and are heterogeneous with varying diagnostic tools used to assess cognitive function. Trial registration PROSPERO Registration: CRD42020161640. DOI 10.1186/s12877-021-02721-w Indigenous content off Field of Research 1103 Clinical Sciences 1106 Human Movement and Sports Sciences HERDC Research category C1 Refereed article in a scholarly journal Free to Read? Yes Persistent URL http://hdl.handle.net/10536/DRO/DU:30161404 Document type: Journal Article Collections: Faculty of Health School of Exercise and Nutrition Sciences Open Access Collection Related Links Link Description Link to full-text (open access)   Connect to Elements publication management system Go to link with your DU access privileges     Unless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved. Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au. Versions Version Filter Type Thu, 13 Jan 2022, 08:28:32 EST Thu, 13 Jan 2022, 14:53:34 EST Sat, 22 Jan 2022, 01:33:29 EST Tue, 25 Jan 2022, 15:20:53 EST Sat, 05 Feb 2022, 01:45:45 EST Wed, 23 Feb 2022, 13:02:51 EST Wed, 23 Feb 2022, 15:35:15 EST Wed, 23 Feb 2022, 15:38:12 EST Tue, 01 Mar 2022, 08:25:55 EST Tue, 01 Mar 2022, 09:45:41 EST Filtered Full Citation counts:   Cited 0 times in TR Web of Science Cited 0 times in Scopus Search Google Scholar Access Statistics: 50 Abstract Views, 0 File Downloads  -  Detailed Statistics Created: Thu, 13 Jan 2022, 08:28:32 EST