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Optimization of Ultrasound-Assisted Extraction of Flavonoids from Celastrus hindsii Leaves Using Response Surface Methodology and Evaluation of Their Antioxidant and Antitumor Activities

Pham, DC, Nguyen, Hoang Chinh, Nguyen, THL, Ho, HL, Trinh, TK, Riyaphan, J and Weng, CF 2020, Optimization of Ultrasound-Assisted Extraction of Flavonoids from Celastrus hindsii Leaves Using Response Surface Methodology and Evaluation of Their Antioxidant and Antitumor Activities, BioMed Research International, vol. 2020, doi: 10.1155/2020/3497107.

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Title Optimization of Ultrasound-Assisted Extraction of Flavonoids from Celastrus hindsii Leaves Using Response Surface Methodology and Evaluation of Their Antioxidant and Antitumor Activities
Author(s) Pham, DC
Nguyen, Hoang Chinh
Nguyen, THL
Ho, HL
Trinh, TK
Riyaphan, J
Weng, CF
Journal name BioMed Research International
Volume number 2020
Article ID ARTN 3497107
Total pages 9
Publisher HINDAWI LTD
Place of publication United States
Publication date 2020-01-01
ISSN 2314-6133
2314-6141
Keyword(s) Science & Technology
Life Sciences & Biomedicine
Biotechnology & Applied Microbiology
Medicine, Research & Experimental
Research & Experimental Medicine
IN-VITRO
ANTICANCER ACTIVITIES
POLYSACCHARIDES
CANCER
BARK
Summary Celastrus hindsii is a potential source of flavonoids with biological activities. This study aimed to develop an ultrasound-assisted technique for extracting flavonoids from leaves of C. hindsii. Response surface methodology was employed to optimize the extraction conditions for maximizing the total flavonoid content (TFC). A maximum TFC of 23.6 mg QE/g was obtained under the extraction conditions of ultrasonic power of 130 W, extraction temperature of 40°C, extraction time of 29 min, and ethanol concentration of 65%. The flavonoid-rich extracts were then studied for their antioxidant and anticancer activities. The results showed that the C. hindsii leaf extract exhibited potent radical scavenging activities against DPPH (IC50 of 164.85 μg/mL) and ABTS (IC50 of 89.05 μg/mL). The extract also significantly inhibited the growth of 3 cancer cell lines MCF7, A549, and HeLa with the IC50 values of 88.1 μg/mL, 120.4 μg/mL, and 118.4 μg/mL, respectively. Notably, the extract had no cytotoxicity effect on HK2 normal kidney cell line. This study suggests that flavonoid-rich extract is a promising antioxidant and anticancer agent and that ultrasound-assisted extraction is an efficient method for extracting flavonoids from C. hindsii leaves.
Language eng
DOI 10.1155/2020/3497107
Indigenous content off
Field of Research 06 Biological Sciences
08 Information and Computing Sciences
10 Technology
HERDC Research category C1.1 Refereed article in a scholarly journal
Free to Read? Yes
Persistent URL http://hdl.handle.net/10536/DRO/DU:30162166

Document type: Journal Article
Collections: Faculty of Science, Engineering and Built Environment
School of Life and Environmental Sciences
Open Access Collection
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Citation counts: TR Web of Science Citation Count  Cited 11 times in TR Web of Science
Scopus Citation Count Cited 17 times in Scopus Google Scholar Search Google Scholar
Access Statistics: 18 Abstract Views, 0 File Downloads  -  Detailed Statistics
Created: Thu, 03 Feb 2022, 13:10:56 EST

Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.