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Evaluation of the use of different solvents for phytochemical constituents, antioxidants, and in vitro anti-inflammatory activities of severinia buxifolia

Truong, DH, Nguyen, DH, Ta, NTA, Bui, AV, Do, TH and Nguyen, Hoang Chinh 2019, Evaluation of the use of different solvents for phytochemical constituents, antioxidants, and in vitro anti-inflammatory activities of severinia buxifolia, Journal of Food Quality, vol. 2019, pp. 1-9, doi: 10.1155/2019/8178294.

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Title Evaluation of the use of different solvents for phytochemical constituents, antioxidants, and in vitro anti-inflammatory activities of severinia buxifolia
Author(s) Truong, DH
Nguyen, DH
Ta, NTA
Bui, AV
Do, TH
Nguyen, Hoang Chinh
Journal name Journal of Food Quality
Volume number 2019
Article ID 8178294
Start page 1
End page 9
Total pages 9
Publisher Wiley
Place of publication London, Eng.
Publication date 2019-02-03
ISSN 0146-9428
1745-4557
Keyword(s) ATALANTIA-BUXIFOLIA
BARK
Food Science & Technology
Life Sciences & Biomedicine
METHANOL EXTRACTS
PARTS
Science & Technology
TOTAL FLAVONOID CONTENT
Summary Severinia buxifolia (Rutaceae) is a promising source of bioactive compounds since it has been traditionally used for the treatment of various diseases. The present study aimed at evaluating the impact of different solvents on extraction yields, phytochemical constituents and antioxidants, and in vitro anti-inflammatory activities of S. buxifolia. The results showed that the used solvents took an important role in the yield of extraction, the content of chemical components, and the tested biological activities. Methanol was identified as the most effective solvent for the extraction, resulting in the highest extraction yield (33.2%) as well as the highest content of phenolic (13.36 mg GAE/g DW), flavonoid (1.92 mg QE/g DW), alkaloid (1.40 mg AE/g DW), and terpenoids (1.25%, w/w). The extract obtained from methanol exhibited high capacity of antioxidant (IC50 value of 16.99 μg/mL) and in vitro anti-inflammatory activity (i.e., albumin denaturation: IC50 = 28.86 μg/mL; antiproteinase activity: IC50 = 414.29 μg/mL; and membrane stabilization: IC50 = 319 μg/mL). The antioxidant activity of the S. buxifolia extract was found to be 3-fold higher than ascorbic acid, and the anti-inflammatory activity of S. buxifolia extract was comparable to aspirin. Therefore, methanol is recommended as the optimal solvent to obtain high content of phytochemical constituents as well as high antioxidants and in vitro anti-inflammatory constituents from the branches of S. buxifolia for utilization in pharmacognosy.
Language eng
DOI 10.1155/2019/8178294
Indigenous content off
Field of Research 0908 Food Sciences
HERDC Research category C1.1 Refereed article in a scholarly journal
Free to Read? Yes
Persistent URL http://hdl.handle.net/10536/DRO/DU:30162175

Document type: Journal Article
Collections: Faculty of Science, Engineering and Built Environment
School of Life and Environmental Sciences
Open Access Collection
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Citation counts: TR Web of Science Citation Count  Cited 153 times in TR Web of Science
Scopus Citation Count Cited 195 times in Scopus Google Scholar Search Google Scholar
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Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.