Conducting Clinical Trials in Twin Populations: A Review of Design, Analysis, Recruitment and Ethical Issues for Twin-Only Trials Yelland, LN, Scurrah, KJ, Ferreira, P, Calais-Ferreira, L, Rankin, M, Denton, J, Harvey, M, Lee, KJ, Kendal, E and Craig, Jeffrey 2022, Conducting Clinical Trials in Twin Populations: A Review of Design, Analysis, Recruitment and Ethical Issues for Twin-Only Trials, Twin Research and Human Genetics, vol. 24, no. 6, pp. 359-364, doi: 10.1017/thg.2021.52. Attached Files Name Description MIMEType Size Downloads Title Conducting Clinical Trials in Twin Populations: A Review of Design, Analysis, Recruitment and Ethical Issues for Twin-Only Trials Author(s) Yelland, LN Scurrah, KJ Ferreira, P Calais-Ferreira, L Rankin, M Denton, J Harvey, M Lee, KJ Kendal, E Craig, Jeffrey orcid.org/0000-0003-3979-7849 Journal name Twin Research and Human Genetics Volume number 24 Issue number 6 Start page 359 End page 364 Total pages 6 Publisher Cambridge University Press Place of publication Cambridge, Eng. Publication date 2022 ISSN 1832-4274 1839-2628 Keyword(s) Analysis clinical trials design ethics Genetics & Heredity HEALTH INTERVENTION Life Sciences & Biomedicine MODELS Obstetrics & Gynecology RANDOMIZATION recruitment SAMPLE-SIZE Science & Technology twins Summary AbstractAlthough twins often participate in medical research, few clinical trials are conducted entirely in twin populations. The purpose of this review is to demonstrate the substantial benefits and address the key challenges of conducting clinical trials in twin populations, or ‘twin-only trials’. We consider the unique design, analysis, recruitment and ethical issues that arise in such trials. In particular, we describe the different approaches available for randomizing twin pairs, highlight the similarity or correlation that exists between outcomes of twins, and discuss the impact of this correlation on sample size calculations and statistical analysis methods for estimating treatment effects. We also consider the role of both monozygotic and dizygotic twins for studying variation in outcomes, the factors that may affect recruitment of twins, and the ethics of conducting trials entirely in twin populations. The advantages and disadvantages of conducting twin-only trials are also discussed. Finally, we recommend that twin-only trials should be considered more often. Language eng DOI 10.1017/thg.2021.52 Field of Research 1103 Clinical Sciences 1114 Paediatrics and Reproductive Medicine 1702 Cognitive Sciences HERDC Research category C1 Refereed article in a scholarly journal Persistent URL http://hdl.handle.net/10536/DRO/DU:30162410 Document type: Journal Article Collections: Faculty of Health School of Medicine Related Links Link Description Connect to published version Go to link with your DU access privileges   Connect to Elements publication management system Go to link with your DU access privileges     Unless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved. Versions Version Filter Type Fri, 11 Feb 2022, 07:49:56 EST Fri, 11 Feb 2022, 14:41:04 EST Fri, 11 Feb 2022, 14:42:35 EST Wed, 16 Feb 2022, 16:08:46 EST Sat, 19 Feb 2022, 01:45:39 EST Wed, 06 Apr 2022, 16:32:03 EST Wed, 06 Apr 2022, 16:46:23 EST Wed, 06 Apr 2022, 16:54:16 EST Filtered Full Citation counts:   Cited 0 times in TR Web of Science Cited 0 times in Scopus Search Google Scholar Access Statistics: 13 Abstract Views, 2 File Downloads  -  Detailed Statistics Created: Fri, 11 Feb 2022, 07:49:56 EST