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The effect of breaking up prolonged sitting on paired associative stimulation-induced plasticity

Bojsen-Møller, E, Ekblom, MM, Tarassova, O, Dunstan, David and Ekblom, O 2020, The effect of breaking up prolonged sitting on paired associative stimulation-induced plasticity, Experimental Brain Research, vol. 238, pp. 2497-2506, doi: 10.1007/s00221-020-05866-z.

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Title The effect of breaking up prolonged sitting on paired associative stimulation-induced plasticity
Author(s) Bojsen-Møller, E
Ekblom, MM
Tarassova, O
Dunstan, DavidORCID iD for Dunstan, David orcid.org/0000-0003-2629-9568
Ekblom, O
Journal name Experimental Brain Research
Volume number 238
Start page 2497
End page 2506
Total pages 10
Publisher Springer
Place of publication Heidelberg, Germany
Publication date 2020
ISSN 0014-4819
1432-1106
Keyword(s) Corticospinal excitability
Paired associative stimulation
Sedentary behaviour
Transcranial magnetic stimulation
Summary Paired associative stimulation (PAS) can induce plasticity in the motor cortex, as measured by changes in corticospinal excitability (CSE). This effect is attenuated in older and less active individuals. Although a single bout of exercise enhances PAS-induced plasticity in young, physically inactive adults, it is not yet known if physical activity interventions affect PAS-induced neuroplasticity in middle-aged inactive individuals. Sixteen inactive middle-aged office workers participated in a randomized cross-over design investigating how CSE and short-interval intracortical inhibition (SICI) were affected by PAS preceded by 3 h of sitting (SIT), 3 h of sitting interrupted every 30 min by 3 min of frequent short bouts of physical activity (FPA) and 2.5 h of sitting followed by 25 min of moderate-intensity exercise (EXE). Transcranial magnetic stimulation was applied over the primary motor cortex (M1) of the dominant abductor pollicis brevis to induce recruitment curves before and 5 min and 30 min post-PAS. Linear mixed models were used to compare changes in CSE using time and condition as fixed effects and subjects as random effects. There was a main effect of time on CSE and planned within-condition comparisons showed that CSE was significantly increased from baseline to 5 min and 30 min post-PAS, in the FPA condition, with no significant changes in the SIT or EXE conditions. SICI decreased from baseline to 5 min post-PAS, but this was not related to changes in CSE. Our findings suggest that in middle-aged inactive adults, FPAs may promote corticospinal neuroplasticity. Possible mechanisms are discussed.
Language eng
DOI 10.1007/s00221-020-05866-z
Field of Research 11 Medical and Health Sciences
17 Psychology and Cognitive Sciences
HERDC Research category C1 Refereed article in a scholarly journal
Free to Read? Yes
Persistent URL http://hdl.handle.net/10536/DRO/DU:30162666

Document type: Journal Article
Collections: Faculty of Health
School of Exercise and Nutrition Sciences
Open Access Collection
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Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.