The effect of breaking up prolonged sitting on paired associative stimulation-induced plasticity Bojsen-Møller, E, Ekblom, MM, Tarassova, O, Dunstan, David and Ekblom, O 2020, The effect of breaking up prolonged sitting on paired associative stimulation-induced plasticity, Experimental Brain Research, vol. 238, pp. 2497-2506, doi: 10.1007/s00221-020-05866-z. Attached Files Name Description MIMEType Size Downloads Title The effect of breaking up prolonged sitting on paired associative stimulation-induced plasticity Author(s) Bojsen-Møller, E Ekblom, MM Tarassova, O Dunstan, David orcid.org/0000-0003-2629-9568 Ekblom, O Journal name Experimental Brain Research Volume number 238 Start page 2497 End page 2506 Total pages 10 Publisher Springer Place of publication Heidelberg, Germany Publication date 2020 ISSN 0014-4819 1432-1106 Keyword(s) Corticospinal excitability Paired associative stimulation Sedentary behaviour Transcranial magnetic stimulation Summary Paired associative stimulation (PAS) can induce plasticity in the motor cortex, as measured by changes in corticospinal excitability (CSE). This effect is attenuated in older and less active individuals. Although a single bout of exercise enhances PAS-induced plasticity in young, physically inactive adults, it is not yet known if physical activity interventions affect PAS-induced neuroplasticity in middle-aged inactive individuals. Sixteen inactive middle-aged office workers participated in a randomized cross-over design investigating how CSE and short-interval intracortical inhibition (SICI) were affected by PAS preceded by 3 h of sitting (SIT), 3 h of sitting interrupted every 30 min by 3 min of frequent short bouts of physical activity (FPA) and 2.5 h of sitting followed by 25 min of moderate-intensity exercise (EXE). Transcranial magnetic stimulation was applied over the primary motor cortex (M1) of the dominant abductor pollicis brevis to induce recruitment curves before and 5 min and 30 min post-PAS. Linear mixed models were used to compare changes in CSE using time and condition as fixed effects and subjects as random effects. There was a main effect of time on CSE and planned within-condition comparisons showed that CSE was significantly increased from baseline to 5 min and 30 min post-PAS, in the FPA condition, with no significant changes in the SIT or EXE conditions. SICI decreased from baseline to 5 min post-PAS, but this was not related to changes in CSE. Our findings suggest that in middle-aged inactive adults, FPAs may promote corticospinal neuroplasticity. Possible mechanisms are discussed. Language eng DOI 10.1007/s00221-020-05866-z Field of Research 11 Medical and Health Sciences 17 Psychology and Cognitive Sciences HERDC Research category C1 Refereed article in a scholarly journal Free to Read? Yes Persistent URL http://hdl.handle.net/10536/DRO/DU:30162666 Document type: Journal Article Collections: Faculty of Health School of Exercise and Nutrition Sciences Open Access Collection Related Links Link Description Link to full-text (open access)   Connect to Elements publication management system Go to link with your DU access privileges     Unless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved. Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au. Versions Version Filter Type Thu, 17 Feb 2022, 11:49:54 EST Thu, 17 Feb 2022, 14:50:57 EST Thu, 17 Feb 2022, 14:57:09 EST Wed, 23 Feb 2022, 05:05:18 EST Wed, 06 Apr 2022, 12:17:53 EST Wed, 06 Apr 2022, 16:15:06 EST Wed, 06 Apr 2022, 16:21:55 EST Filtered Full Citation counts:   Cited 0 times in TR Web of Science Cited 3 times in Scopus Search Google Scholar Access Statistics: 18 Abstract Views, 0 File Downloads  -  Detailed Statistics Created: Thu, 17 Feb 2022, 11:49:54 EST