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Morning exercise mitigates the impact of prolonged sitting on cerebral blood flow in older adults

Wheeler, MJ, Dunstan, David, Smith, B, Smith, KJ, Scheer, A, Lewis, J, Naylor, LH, Heinonen, I, Ellis, KA, Cerin, E, Ainslie, PN and Green, DJ 2019, Morning exercise mitigates the impact of prolonged sitting on cerebral blood flow in older adults, Journal of Applied Physiology, vol. 126, no. 4, pp. 1049-1055, doi: 10.1152/japplphysiol.00001.2019.

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Title Morning exercise mitigates the impact of prolonged sitting on cerebral blood flow in older adults
Author(s) Wheeler, MJ
Dunstan, DavidORCID iD for Dunstan, David orcid.org/0000-0003-2629-9568
Smith, B
Smith, KJ
Scheer, A
Lewis, J
Naylor, LH
Heinonen, I
Ellis, KA
Cerin, E
Ainslie, PN
Green, DJ
Journal name Journal of Applied Physiology
Volume number 126
Issue number 4
Start page 1049
End page 1055
Total pages 7
Publisher American Physiological Society
Place of publication Bethesda, Md.
Publication date 2019-04-01
ISSN 1522-1601
1522-1601
Keyword(s) acute exercise
BRAIN
brain health
BREAKS
DISEASE
Life Sciences & Biomedicine
NEUROGENESIS
older adults
PHYSICAL-ACTIVITY
Physiology
RATIONALE
RISK
Science & Technology
sedentary behavior
Sport Sciences
TIME
transcranial Doppler
Summary Preventing declines in cerebral blood flow is important for maintaining optimal brain health with aging. We compared the effects of a morning bout of moderate-intensity exercise, with and without subsequent light-intensity walking breaks from sitting, on cerebral blood velocity over 8 h in older adults. In a randomized crossover trial, overweight/obese older adults ( n = 12, 70 ± 7 yr; 30.4 ± 4.3 kg/m2), completed three acute conditions (6-day washout); SIT: prolonged sitting (8 h, control); EX+SIT: sitting (1 h), moderate-intensity walking (30 min), followed by uninterrupted sitting (6.5 h); and EX + BR: sitting (1 h), moderate-intensity walking (30 min), followed by sitting (6.5 h) interrupted with 3 min of light-intensity walking every 30 min. Bilateral middle cerebral artery velocities (MCAv) were determined using transcranial Doppler at 13 time points across the day. The temporal pattern and average MCAv over 8 h was determined. The pattern of MCAv over 8 h was a negative linear trend in SIT ( P < 0.001), but a positive quadratic trend in EX + SIT ( P < 0.001) and EX + BR ( P < 0.01). Afternoon time points in SIT were lower than baseline within condition ( P ≤ 0.001 for all). A morning dip in MCAv was observed in EX + SIT and EX + BR ( P < 0.05 relative to baseline), but afternoon time points were not significantly lower than baseline. The average MCAv over 8 h was higher in EX + SIT than SIT ( P = 0.007) or EX + BR ( P = 0.024). Uninterrupted sitting should be avoided, and moderate-intensity exercise should be encouraged for the daily maintenance of cerebral blood flow in older adults. The clinical implications of maintaining adequate cerebral blood flow include the delivery of vital oxygen and nutrients to the brain. NEW & NOTEWORTHY This is the first study to measure the combined effects of an exercise bout with breaks in sitting on cerebral blood velocity in older adults. Using frequent recordings over an 8-h period, we have performed a novel analysis of the pattern of cerebral blood velocity, adjusting for concurrent measures of mean arterial pressure and other potential confounders in a linear mixed effects regression.
Language eng
DOI 10.1152/japplphysiol.00001.2019
Indigenous content off
Field of Research 06 Biological Sciences
11 Medical and Health Sciences
HERDC Research category C1 Refereed article in a scholarly journal
Free to Read? Yes
Persistent URL http://hdl.handle.net/10536/DRO/DU:30162688

Document type: Journal Article
Collections: Faculty of Health
School of Exercise and Nutrition Sciences
Open Access Collection
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Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.