The association of weight change and all-cause mortality in older adults: a systematic review and meta-analysis Alharbi, TA, Paudel, S, Gasevic, D, Ryan, J, Freak-Poli, R and Owen, AJ 2021, The association of weight change and all-cause mortality in older adults: a systematic review and meta-analysis, Age and ageing, vol. 50, no. 3, pp. 697-704, doi: 10.1093/ageing/afaa231. Attached Files Name Description MIMEType Size Downloads Title The association of weight change and all-cause mortality in older adults: a systematic review and meta-analysis Author(s) Alharbi, TA Paudel, S Gasevic, D Ryan, J Freak-Poli, R Owen, AJ Journal name Age and ageing Volume number 50 Issue number 3 Start page 697 End page 704 Total pages 8 Publisher Oxford University Press Place of publication Oxford, Eng. Publication date 2021-05 ISSN 0002-0729 1468-2834 Keyword(s) all-cause mortality body mass index (BMI) Geriatrics & Gerontology HEALTH IMPACT meta-analysis older people POPULATION RISK systematic review weight change Science & Technology Life Sciences & Biomedicine BODY-MASS-INDEX MEN Summary Abstract Objective there may be age-related differences in the impact of weight change on health. This study systematically reviewed the evidence on the relationship between weight change and all-cause mortality in adults aged 65 years and older. Methods MEDLINE, EMBASE and CINAHL were searched from inception to 11 June 2020, PROSPERO CRD 42019142268. We included observational studies reporting on the association between weight change and all-cause mortality in older community-dwelling adults. A random-effects meta-analysis was performed to calculate pooled hazard ratios and scored based on the Agency for Healthcare Research and Quality guidelines. Results a total of 30 studies, including 1,219,279 participants with 69,255 deaths, demonstrated that weight loss was associated with a 59% increase in mortality risk (hazard ratio (HR): 1.59; 95% confidence interval (CI): 1.45–1.74; P < 0.001). Twenty-seven studies that reported outcomes for weight gain (1,210,116 participants with 65,481 deaths) indicated that weight gain was associated with a 10% increase in all-cause mortality (HR: 1.10; 95%CI: 1.02, 1.17; P = 0.01). Four studies investigated weight fluctuation (2,283 events among 6,901 participants), which was associated with a 63% increased mortality risk (HR: 1.66; 95%CI: 1.28, 2.15). No evidence of publication bias was observed (all P > 0.05). Conclusion for community-dwelling older adults, weight changes (weight loss, gain or weight fluctuation) are associated with an increased risk of all-cause mortality risk relative to stable weight. Further research is needed to determine whether these associations vary depending upon initial weight, and whether or not the weight loss/gain was intentional. Language eng DOI 10.1093/ageing/afaa231 Field of Research 1103 Clinical Sciences 1117 Public Health and Health Services 1701 Psychology HERDC Research category C1 Refereed article in a scholarly journal Persistent URL http://hdl.handle.net/10536/DRO/DU:30163616 Document type: Journal Article Collections: Faculty of Health School of Exercise and Nutrition Sciences Related Links Link Description Connect to published version Go to link with your DU access privileges   Author URL Go to link with your DU access privileges   Connect to Elements publication management system Go to link with your DU access privileges     Unless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved. Versions Version Filter Type Mon, 28 Feb 2022, 09:43:55 EST Mon, 28 Feb 2022, 15:31:22 EST Mon, 07 Mar 2022, 14:50:57 EST Tue, 05 Apr 2022, 15:10:37 EST Tue, 05 Apr 2022, 16:44:12 EST Tue, 05 Apr 2022, 16:46:42 EST Filtered Full Citation counts:   Cited 4 times in TR Web of Science Cited 5 times in Scopus Search Google Scholar Access Statistics: 8 Abstract Views, 0 File Downloads  -  Detailed Statistics Created: Mon, 28 Feb 2022, 09:43:55 EST