Innate Immune Activation and Circulating Inflammatory Markers in Preschool Children Collier, F, Chau, C, Mansell, T, Faye-Chauhan, K, Vuillermin, Peter, Ponsonby, AL, Saffery, R, Tang, MLK, O’Hely, M, Carlin, J, Gray, Lawrence, Bekkering, S and Burgner, D 2022, Innate Immune Activation and Circulating Inflammatory Markers in Preschool Children, Frontiers in Immunology, vol. 12, pp. 1-8, doi: 10.3389/fimmu.2021.830049. Attached Files Name Description MIMEType Size Downloads Title Innate Immune Activation and Circulating Inflammatory Markers in Preschool Children Author(s) Collier, F Chau, C Mansell, T Faye-Chauhan, K Vuillermin, Peter orcid.org/0000-0002-6580-0346 Ponsonby, AL Saffery, R Tang, MLK O’Hely, M Carlin, J Gray, Lawrence Bekkering, S Burgner, D Journal name Frontiers in Immunology Volume number 12 Article ID ARTN 830049 Start page 1 End page 8 Total pages 8 Publisher Frontiers Media Place of publication Lausanne, Switzerland Publication date 2022-02-08 ISSN 1664-3224 1664-3224 Keyword(s) cytokines DISEASE EXPRESSION human functional genomics IL-10 Immunology innate immune activation Life Sciences & Biomedicine preschool children Science & Technology SEX-DIFFERENCES STIMULATION systemic inflammation Barwon Infant Study Investigator Group Summary Early childhood is characterised by repeated infectious exposures that result in inflammatory responses by the innate immune system. In addition, this inflammatory response to infection is thought to contribute to the epidemiological evidence linking childhood infection and adult non-communicable diseases. Consequently, the relationship between innate immune responses and inflammation during early life may inform prevention of NCDs later in life. In adults, non-genetic host factors such as age, sex, and obesity, strongly impact cytokine production and circulating mediators, but data in children are lacking. Here, we assessed cytokine responses and inflammatory markers in a population of healthy preschool children (mean age 4.2 years). We studied associations between cytokines, plasma inflammatory markers and non-genetic host factors, such as sex, age, adiposity, season, and immune cell composition. Similar to adults, boys had a higher inflammatory response than girls, with IL-12p70 and IL-10 upregulated following TLR stimulation. Adiposity and winter season were associated with increased circulating inflammatory markers but not cytokine production. The inflammatory markers GlycA and hsCRP were positively associated with production of a number of cytokines and may therefore reflect innate immune function and inflammatory potential. This dataset will be informative for future prospective studies relating immune parameters to preclinical childhood NCD phenotypes. Language eng DOI 10.3389/fimmu.2021.830049 Field of Research 1107 Immunology 1108 Medical Microbiology HERDC Research category C1 Refereed article in a scholarly journal Free to Read? Yes Persistent URL http://hdl.handle.net/10536/DRO/DU:30163626 Document type: Journal Article Collections: Faculty of Health School of Medicine Open Access Collection Related Links Link Description Link to full-text (open access)   Connect to published version Go to link with your DU access privileges   Connect to Elements publication management system Go to link with your DU access privileges     Unless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved. Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au. Versions Version Filter Type Mon, 28 Feb 2022, 10:11:08 EST Mon, 28 Feb 2022, 15:31:33 EST Sat, 05 Mar 2022, 01:46:23 EST Mon, 07 Mar 2022, 14:51:36 EST Sat, 19 Mar 2022, 01:31:13 EST Thu, 07 Apr 2022, 11:43:45 EST Thu, 07 Apr 2022, 15:42:15 EST Thu, 07 Apr 2022, 15:46:02 EST Fri, 08 Apr 2022, 17:35:33 EST Filtered Full Citation counts:   Cited 0 times in TR Web of Science Cited 0 times in Scopus Search Google Scholar Access Statistics: 13 Abstract Views, 0 File Downloads  -  Detailed Statistics Created: Mon, 28 Feb 2022, 10:11:08 EST