Trajectories of childhood immune development and respiratory health relevant to asthma and allergy Tang, HHF, Teo, SM, Belgrave, DCM, Evans, MD, Jackson, DJ, Brozynska, M, Kusel, MMH, Johnston, SL, Gern, JE, Lemanske, RF, Simpson, A, Custovic, A, Sly, Peter, Holt, PG, Holt, KE and Inouye, M 2018, Trajectories of childhood immune development and respiratory health relevant to asthma and allergy, eLife, vol. 7, doi: 10.7554/eLife.35856. Title Trajectories of childhood immune development and respiratory health relevant to asthma and allergy Author(s) Tang, HHF Teo, SM Belgrave, DCM Evans, MD Jackson, DJ Brozynska, M Kusel, MMH Johnston, SL Gern, JE Lemanske, RF Simpson, A Custovic, A Sly, Peter Holt, PG Holt, KE Inouye, M Journal name eLife Volume number 7 Article ID e35856 Publisher eLife Sciences Publications Place of publication Cambridge, Eng. Publication date 2018-10 ISSN 2050-084X 2050-084X Keyword(s) ATOPY PHENOTYPES Biology Life Sciences & Biomedicine PATTERNS PEANUT ALLERGY PREDICTION RISK Science & Technology Life Sciences & Biomedicine - Other Topics 1ST 6 YEARS VIRAL-INFECTIONS YOUNG-CHILDREN FOLLOW-UP SENSITIZATION allergy bioinformatics computational biology human immune development respiratory disease systems biology Summary Events in early life contribute to subsequent risk of asthma; however, the causes and trajectories of childhood wheeze are heterogeneous and do not always result in asthma. Similarly, not all atopic individuals develop wheeze, and vice versa. The reasons for these differences are unclear. Using unsupervised model-based cluster analysis, we identified latent clusters within a prospective birth cohort with deep immunological and respiratory phenotyping. We characterised each cluster in terms of immunological profile and disease risk, and replicated our results in external cohorts from the UK and USA. We discovered three distinct trajectories, one of which is a high-risk ‘atopic’ cluster with increased propensity for allergic diseases throughout childhood. Atopy contributes varyingly to later wheeze depending on cluster membership. Our findings demonstrate the utility of unsupervised analysis in elucidating heterogeneity in asthma pathogenesis and provide a foundation for improving management and prevention of childhood asthma. Language eng DOI 10.7554/eLife.35856 Field of Research 0601 Biochemistry and Cell Biology HERDC Research category C1 Refereed article in a scholarly journal Free to Read? Yes Persistent URL http://hdl.handle.net/10536/DRO/DU:30164836 Document type: Journal Article Collections: Faculty of Health School of Medicine Open Access Collection Related Links Link Description Link to full-text (open access)   Connect to published version Go to link with your DU access privileges   Author URL Go to link with your DU access privileges   Connect to Elements publication management system Go to link with your DU access privileges     Unless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved. Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au. Versions Version Filter Type Mon, 21 Mar 2022, 07:45:42 EST Mon, 21 Mar 2022, 17:31:48 EST Wed, 06 Apr 2022, 09:02:22 EST Thu, 21 Apr 2022, 15:32:08 EST Thu, 21 Apr 2022, 16:32:13 EST Thu, 21 Apr 2022, 16:59:14 EST Thu, 05 May 2022, 22:35:50 EST Filtered Full Citation counts:   Cited 10 times in TR Web of Science Cited 11 times in Scopus Search Google Scholar Access Statistics: 8 Abstract Views  -  Detailed Statistics Created: Mon, 21 Mar 2022, 07:45:42 EST