Mapping cognitive deficits in cancer patients after chemotherapy: An Activation Likelihood Estimation meta-analysis of task-related fMRI studies. Saward, Jacqueline Brooke, Ellis, EG, Cobden, AL and Caeyenberghs, Karen 2022, Mapping cognitive deficits in cancer patients after chemotherapy: An Activation Likelihood Estimation meta-analysis of task-related fMRI studies., Brain Imaging Behav, doi: 10.1007/s11682-022-00655-4. Attached Files Name Description MIMEType Size Downloads Title Mapping cognitive deficits in cancer patients after chemotherapy: An Activation Likelihood Estimation meta-analysis of task-related fMRI studies. Author(s) Saward, Jacqueline Brooke Ellis, EG Cobden, AL orcid.org/0000-0001-7009-6843 Caeyenberghs, Karen Journal name Brain Imaging Behav Publisher p Place of publication United States Publication date 2022-04-02 ISSN 1931-7565 Keyword(s) Activation Likelihood Estimation Cancer Chemotherapy Cognitive deficits Functional MRI Summary Recent neuroimaging studies have reported alterations in brain activation during cognitive tasks in cancer patients who have undergone chemotherapy treatment. However, the location of these altered brain activation patterns after chemotherapy varies considerably across studies. The aim of the present meta-analysis was to quantitatively synthesise this body of evidence using Activation Likelihood Estimation to identify reliable regions of altered brain activation in cancer patients treated with chemotherapy, compared to healthy controls and no chemotherapy controls. Our systematic search identified 12 studies that adopted task-related fMRI on non-central nervous system cancer patients who received chemotherapy relative to controls. All studies were included in the analyses and were grouped into four contrasts. Cancer patients treated with chemotherapy showed reduced activation in the left superior parietal lobe/precuneus (family-wise error corrected p < .05) compared to no chemotherapy controls. No significant clusters were found in three of our contrasts. The majority of studies did not support an association between altered brain activation and cognitive performance after chemotherapy. Findings point towards a possible chemotherapy-induced alteration, which could inform targeted treatment strategies. With continued work in this field using homogenous task-related protocols and cancer populations, fMRI may be used as a biomarker of cognitive deficits in the future. Language eng DOI 10.1007/s11682-022-00655-4 Indigenous content off Field of Research 11 Medical and Health Sciences 17 Psychology and Cognitive Sciences Free to Read? Yes Persistent URL http://hdl.handle.net/10536/DRO/DU:30166504 Document type: Journal Article Collections: Faculty of Health School of Psychology Open Access Collection Related Links Link Description Link to full-text (open access)   Connect to published version Go to link with your DU access privileges   Author URL Go to link with your DU access privileges   Connect to Elements publication management system Go to link with your DU access privileges     Unless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved. Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au. Versions Version Filter Type Wed, 06 Apr 2022, 08:32:14 EST Wed, 06 Apr 2022, 08:50:42 EST Thu, 28 Apr 2022, 06:03:47 EST Sun, 01 May 2022, 16:04:54 EST Mon, 02 May 2022, 14:05:43 EST Thu, 05 May 2022, 23:36:16 EST Filtered Full Citation counts:   Cited 0 times in TR Web of Science Cited 0 times in Scopus Search Google Scholar Access Statistics: 9 Abstract Views, 0 File Downloads  -  Detailed Statistics Created: Wed, 06 Apr 2022, 08:32:14 EST