A Hydrogel as a Bespoke Delivery Platform for Stromal Cell-Derived Factor-1 Wang, Y, Penna, V, Williams, Richard, Parish, CL and Nisbet, DR 2022, A Hydrogel as a Bespoke Delivery Platform for Stromal Cell-Derived Factor-1, Gels, vol. 8, no. 4, pp. 224-224, doi: 10.3390/gels8040224. Title A Hydrogel as a Bespoke Delivery Platform for Stromal Cell-Derived Factor-1 Author(s) Wang, Y Penna, V Williams, Richard orcid.org/0000-0003-3831-8738 Parish, CL Nisbet, DR Journal name Gels Volume number 8 Issue number 4 Start page 224 End page 224 Total pages 1 Publisher MDPI AG Publication date 2022 ISSN 2310-2861 Summary The defined self-assembly of peptides (SAPs) into nanostructured bioactive hydrogels has great potential for repairing traumatic brain injuries, as they maintain a stable, homeostatic environment at an injury site, preventing further degeneration. They also present a bespoke platform to restore function via the naturalistic presentation of therapeutic proteins, such as stromal-cell-derived factor 1 (SDF-1), expressed by meningeal cells. A key challenge to the use of the SDF protein, however, is its rapid diffusion and degradation. Here, we engineered a homeostatic hydrogel produced by incorporating recombinant SDF-1 protein within a self-assembled peptide hydrogel to create a supportive milieu for transplanted cells. Our hydrogel can concomitantly deliver viable primary neural progenitor cells and sustained active SDF-1 to support the nascent graft, resulting in increased neuronal differentiation. Moreover, this homeostatic hydrogel can ensure a healthy and larger graft core without impeding neuronal fiber growth and innervation. These findings demonstrate the regenerative potential of these hydrogels to improve the integration of grafted cells to treat neural injuries and diseases. DOI 10.3390/gels8040224 Indigenous content off Free to Read? Yes Persistent URL http://hdl.handle.net/10536/DRO/DU:30166611 Document type: Journal Article Collections: Faculty of Health School of Medicine Open Access Collection Related Links Link Description Link to full-text (open access)   Connect to published version Go to link with your DU access privileges   Connect to Elements publication management system Go to link with your DU access privileges     Unless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved. Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au. Versions Version Filter Type Mon, 11 Apr 2022, 06:50:40 EST Mon, 11 Apr 2022, 15:47:23 EST Mon, 11 Apr 2022, 15:51:25 EST Thu, 14 Apr 2022, 10:35:34 EST Thu, 28 Apr 2022, 06:05:51 EST Mon, 02 May 2022, 10:22:44 EST Mon, 02 May 2022, 14:06:23 EST Thu, 05 May 2022, 23:38:06 EST Filtered Full Citation counts:   Cited 0 times in TR Web of Science Cited 0 times in Scopus Search Google Scholar Access Statistics: 14 Abstract Views  -  Detailed Statistics Created: Mon, 11 Apr 2022, 06:50:40 EST