To the Gut Microbiome and Beyond: The Brain-First or Body-First Hypothesis in Parkinson’s Disease Nuzum, Nathan, Loughman, Amy, Szymlek-Gay, Ewa, Teo, WP, Hendy, Ashlee and Macpherson, Helen 2022, To the Gut Microbiome and Beyond: The Brain-First or Body-First Hypothesis in Parkinson’s Disease, Frontiers in Microbiology, vol. 13, pp. 1-6, doi: 10.3389/fmicb.2022.791213. Attached Files Name Description MIMEType Size Downloads Title To the Gut Microbiome and Beyond: The Brain-First or Body-First Hypothesis in Parkinson’s Disease Author(s) Nuzum, Nathan orcid.org/0000-0002-8627-6192 Loughman, Amy orcid.org/0000-0002-0257-1443 Szymlek-Gay, Ewa orcid.org/0000-0002-6533-7945 Teo, WP Hendy, Ashlee orcid.org/0000-0002-9043-8385 Macpherson, Helen orcid.org/0000-0002-3603-9359 Journal name Frontiers in Microbiology Volume number 13 Article ID ARTN 791213 Start page 1 End page 6 Total pages 6 Publisher Frontiers / Frontiers Media / Frontiers Research Foundation Place of publication Lausanne, Switzerland Publication date 2022-03-30 ISSN 1664-302X 1664-302X Keyword(s) ALPHA-SYNUCLEIN CONSTIPATION DEGENERATION DYSFUNCTION gut flora gut-brain-axis INFLAMMATION Life Sciences & Biomedicine MARKERS Microbiology microbiota microbiota-gut-brain axis neurodegenerative PATHOLOGY RISK Science & Technology SCINTIGRAPHY SLEEP BEHAVIOR DISORDER Summary There is continued debate regarding Parkinson’s disease etiology and whether it originates in the brain or begins in the gut. Recently, evidence has been provided for both, with Parkinson’s disease onset presenting as either a “body-first” or “brain-first” progression. Most research indicates those with Parkinson’s disease have an altered gut microbiome compared to controls. However, some studies do not report gut microbiome differences, potentially due to the brain or body-first progression type. Based on the etiology of each proposed progression, individuals with the body-first progression may exhibit altered gut microbiomes, i.e., where short-chain fatty acid producing bacteria are reduced, while the brain-first progression may not. Future microbiome research should consider this hypothesis and investigate whether gut microbiome differences exist between each type of progression. This may further elucidate the impact of the gut microbiome in Parkinson’s disease and show how it may not be homogenous across individuals with Parkinson’s disease. Language eng DOI 10.3389/fmicb.2022.791213 Indigenous content off Field of Research 0502 Environmental Science and Management 0503 Soil Sciences 0605 Microbiology HERDC Research category C1 Refereed article in a scholarly journal Free to Read? Yes Persistent URL http://hdl.handle.net/10536/DRO/DU:30166911 Document type: Journal Article Collections: Faculty of Health School of Exercise and Nutrition Sciences Open Access Collection Related Links Link Description Connect to Elements publication management system Go to link with your DU access privileges   Link to full text (Open Access) Go to link with your DU access privileges     Unless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved. Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au. Versions Version Filter Type Wed, 20 Apr 2022, 10:04:15 EST Wed, 20 Apr 2022, 14:44:28 EST Wed, 20 Apr 2022, 14:50:07 EST Tue, 26 Apr 2022, 10:32:07 EST Tue, 05 Jul 2022, 16:07:01 EST Fri, 22 Jul 2022, 07:36:01 EST Fri, 22 Jul 2022, 13:37:50 EST Fri, 22 Jul 2022, 13:40:39 EST Fri, 22 Jul 2022, 13:52:03 EST Filtered Full Citation counts:   Cited 0 times in TR Web of Science Cited 0 times in Scopus Search Google Scholar Access Statistics: 18 Abstract Views, 0 File Downloads  -  Detailed Statistics Created: Wed, 20 Apr 2022, 10:04:15 EST