The effect of exercise training on adipose tissue insulin sensitivity: A systematic review and meta-analysis Engin, B, Willis, SA, Malaikah, S, Sargeant, JA, Yates, T, Gray, Laura, Aithal, GP, Stensel, DJ and King, JA 2022, The effect of exercise training on adipose tissue insulin sensitivity: A systematic review and meta-analysis, Obesity Reviews, vol. 23, no. 7, pp. 1-14, doi: 10.1111/obr.13445. Attached Files Name Description MIMEType Size Downloads Title The effect of exercise training on adipose tissue insulin sensitivity: A systematic review and meta-analysis Author(s) Engin, B Willis, SA Malaikah, S Sargeant, JA Yates, T Gray, Laura orcid.org/0000-0002-7903-5796 Aithal, GP Stensel, DJ King, JA Journal name Obesity Reviews Volume number 23 Issue number 7 Article ID e13445 Start page 1 End page 14 Total pages 14 Publisher Wiley Place of publication London, Eng. Publication date 2022-07 ISSN 1467-7881 1467-789X Keyword(s) insulin resistance lipolysis obesity physical activity Summary This systematic review and meta-analysis determined the impact of exercise training on adipose tissue insulin sensitivity in adults. Its scope extended to studies measuring whole-body and localized subcutaneous adipose tissue insulin sensitivity using validated techniques. Consensus from four studies demonstrates that exercise training improved whole-body adipose tissue insulin sensitivity when measured via stable-isotope lipid tracers (rate of appearance suppression in response to hyperinsulinemia). Meta-analysis of 20 studies (26 intervention arms) employing the adipose tissue insulin resistance index (ADIPO-IR) supported these findings (−10.63 [−14.12 to −7.15] pmol·L−1 × mmol·L−1). With ADIPO-IR, this response was greater in studies documenting weight loss and shorter sampling time (≤48 h) post-training. Overall, exercise training did not affect whole-body adipose tissue insulin sensitivity in seven studies (11 intervention arms) measuring the suppression of circulating non-esterified fatty acids in response to insulin infusion (1.51 [−0.12 to 3.14]%); however, subgroup analysis identified an enhanced suppression post-training in trials reporting weight loss. From four microdialysis studies, consensus indicates no effect of exercise training on localized (abdominal/femoral) adipose tissue insulin sensitivity, potentially suggesting that enhanced whole-body responses are related to improvements in central adipose depots. However, heterogeneity within microdialysis protocols dictates that findings must be viewed with caution. Language eng DOI 10.1111/obr.13445 Field of Research 11 Medical and Health Sciences 17 Psychology and Cognitive Sciences HERDC Research category C1 Refereed article in a scholarly journal Persistent URL http://hdl.handle.net/10536/DRO/DU:30168409 Document type: Journal Article Collections: Faculty of Health School of Medicine Related Links Link Description Connect to published version Go to link with your DU access privileges   Connect to Elements publication management system Go to link with your DU access privileges     Unless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved. Versions Version Filter Type Wed, 18 May 2022, 09:51:29 EST Wed, 18 May 2022, 16:29:03 EST Wed, 18 May 2022, 16:39:09 EST Tue, 05 Jul 2022, 16:08:04 EST Fri, 22 Jul 2022, 09:37:13 EST Fri, 22 Jul 2022, 13:38:08 EST Fri, 22 Jul 2022, 13:42:35 EST Filtered Full Citation counts:   Cited 0 times in TR Web of Science Cited 0 times in Scopus Search Google Scholar Access Statistics: 3 Abstract Views, 0 File Downloads  -  Detailed Statistics Created: Wed, 18 May 2022, 09:51:29 EST