The Relationship Between Adverse Childhood Experiences and Alzheimer's Disease: A Systematic Review Corney, KB, West, Emma, Quirk, Shae, Pasco, Julie, Stuart, Amanda, Azimi Manavi, B, Kavanagh, Bianca and Williams, Lana 2022, The Relationship Between Adverse Childhood Experiences and Alzheimer's Disease: A Systematic Review, Frontiers in Aging Neuroscience, vol. 14, pp. 1-10, doi: 10.3389/fnagi.2022.831378. Attached Files Name Description MIMEType Size Downloads Title The Relationship Between Adverse Childhood Experiences and Alzheimer's Disease: A Systematic Review Author(s) Corney, KB West, Emma orcid.org/0000-0001-9559-7003 Quirk, Shae Pasco, Julie orcid.org/0000-0002-8968-4714 Stuart, Amanda orcid.org/0000-0001-8770-9511 Azimi Manavi, B Kavanagh, Bianca orcid.org/0000-0002-1656-2775 Williams, Lana orcid.org/0000-0002-1377-1272 Journal name Frontiers in Aging Neuroscience Volume number 14 Article ID 831378 Start page 1 End page 10 Total pages 10 Publisher Frontiers Place of publication Lausanne, Switzerland Publication date 2022-05 ISSN 1663-4365 Keyword(s) Science & Technology Life Sciences & Biomedicine Geriatrics & Gerontology Neurosciences Neurosciences & Neurology Alzheimer's disease dementia cognitive aging systematic review adverse childhood experience (ACE) RISK STRESS Summary Background: Alzheimer's disease is a global health concern, and with no present cure, prevention is critical. Exposure to adverse childhood experiences may increase the risk of developing Alzheimer's disease. This systematic review was conducted to synthesize the evidence on the associations between adverse childhood experiences (<18 years) and the risk of Alzheimer's disease in adulthood. Methods: A search strategy was developed and conducted to identify articles investigating the associations between exposure to adverse childhood experiences and the onset of Alzheimer's disease by searching key databases (CINAHL, MEDLINE and PsycInfo). Two reviewers independently determined the eligibility of studies according to pre-determined criteria, and assessed the methodological quality using the US National Heart, Lung and Blood Institute 14-item checklist for observational cohort and cross-sectional studies, respectively. Due to limited studies, a descriptive synthesis was performed. The protocol for this review is published in BMJ Open and registered with PROSPERO (CRD42020191439). Results: Our search yielded 781 articles, of which three (two separate analyses from the same cohort study and one cross-sectional study) met the predetermined eligibility criteria. The methodological quality assessment yielded an overall mean score of 78.9% (range 66.6 – 84.6%). All studies found adverse childhood experiences were associated with an increased risk of Alzheimer's disease. However, there was a limited number of available studies to inform the synthesis. Conclusions: Adverse childhood experiences appear to be associated with an increased risk of Alzheimer's disease, although, further research is needed. Language eng DOI 10.3389/fnagi.2022.831378 Field of Research 0601 Biochemistry and Cell Biology 1109 Neurosciences 1702 Cognitive Sciences HERDC Research category C1 Refereed article in a scholarly journal Free to Read? Yes Persistent URL http://hdl.handle.net/10536/DRO/DU:30168886 Document type: Journal Article Collections: Faculty of Health School of Medicine Open Access Collection Related Links Link Description Link to full-text (open access)   Connect to Elements publication management system Go to link with your DU access privileges     Unless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved. Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au. Versions Version Filter Type Mon, 23 May 2022, 08:45:00 EST Mon, 23 May 2022, 16:11:37 EST Mon, 23 May 2022, 16:16:17 EST Tue, 24 May 2022, 09:10:57 EST Wed, 13 Jul 2022, 16:28:47 EST Tue, 19 Jul 2022, 11:17:40 EST Tue, 19 Jul 2022, 13:38:18 EST Tue, 19 Jul 2022, 15:07:37 EST Filtered Full Citation counts:   Cited 0 times in TR Web of Science Cited 0 times in Scopus Search Google Scholar Access Statistics: 14 Abstract Views, 0 File Downloads  -  Detailed Statistics Created: Mon, 23 May 2022, 08:45:00 EST