Hepatoprotective effects of red cabbage in hypercholesterolemic diet-induced oxidative stressed rabbits
Ashfaq, F, Butt, MS, Bilal, A and Suleria, Hafiz 2020, Hepatoprotective effects of red cabbage in hypercholesterolemic diet-induced oxidative stressed rabbits, Current Bioactive Compounds, vol. 16, no. 4, pp. 469-480, doi: 10.2174/1573407215666190124113738.
Title
Hepatoprotective effects of red cabbage in hypercholesterolemic diet-induced oxidative stressed rabbits
Background:Diet-disease linkages are getting immense attention of the scientific fraternity.
In this regard, red cabbage was assessed against hypercholesterolemic and related oxidative damage.
Nowadays, plant bioactives are gaining immense attention among the masses to mitigate lifestyle related
malfunctions. Considering phytochemistry and cost-effectiveness, the current project was designed to
probe the bioefficacy red cabbage against hypercholesterolemic diet related oxidative stress in the liver.Methods:The red cabbage and its aqueous extract were tested on male white New Zealand rabbits for
12 weeks. Two studies were conducted based on dietary regimens; normal and hypercholesterolemic
diet (1% cholesterol). At termination, overnight fasted rabbits were sacrificed to assess serum specific
and tissues biomarkers of hepatic oxidative stress alongside, hepatosomatic index and histopathology
were studied.Results: In hypercholesterolemic diet induced oxidative stressed rabbits, the supplementation of red
cabbage and its aqueous extract suppressed the leakage of liver functioning enzymes in sera up to 15.63
and 12.70% (alanine transaminase), 13.88 and 9.55% (alkaline phosphatase), 12.96 and 8.82% (γ-glutamyl
transferase) and 10.77 and 6.15% (total bilirubin). Besides, the respective diets also portrayed
considerable reduction in hepatic lipid peroxidation up to 29.60 and 23.63% thus improved endogenous
antioxidant enzymes; superoxide dismutase (17.97 and 15.92%) and catalase (24.39 and 20.98%). Furthermore,
hepatosomatic index expounded a significant impact of treatments on oxidative stressed rabbits
alongside mild degree of fibrotic and necrotic changes in their hepatic parenchyma was rectified by
red cabbage, whereas red cabbage extract demonstrated slower rate of amelioration.Conclusion:In the nutshell, dietary inclusions based on red cabbage have shown higher restorative
potential against hepatic oxidative stress as compared to red cabbage aqueous extract.
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