hamilton-hipposignaltransduction-2016.pdf (171.05 kB)
The Hippo signal transduction network for exercise physiologists
journal contribution
posted on 2016-05-15, 00:00 authored by Brendan M Gabriel, Lee HamiltonLee Hamilton, Annie M Tremblay, Henning WackerhageThe ubiquitous transcriptional coactivators Yap (gene symbol Yap1) and Taz (gene symbol Wwtr1) regulate gene expression mainly by coactivating the Tead transcription factors. Being at the center of the Hippo signaling network, Yap and Taz are regulated by the Hippo kinase cassette and additionally by a plethora of exercise-associated signals and signaling modules. These include mechanotransduction, the AKT-mTORC1 network, the SMAD transcription factors, hypoxia, glucose homeostasis, AMPK, adrenaline/epinephrine and angiotensin II through G protein-coupled receptors, and IL-6. Consequently, exercise should alter Hippo signaling in several organs to mediate at least some aspects of the organ-specific adaptations to exercise. Indeed, Tead1 overexpression in muscle fibers has been shown to promote a fast-to-slow fiber type switch, whereas Yap in muscle fibers and cardiomyocytes promotes skeletal muscle hypertrophy and cardiomyocyte adaptations, respectively. Finally, genome-wide association studies in humans have linked the Hippo pathway members LATS2, TEAD1, YAP1, VGLL2, VGLL3, and VGLL4 to body height, which is a key factor in sports.
History
Journal
Journal of applied physiologyVolume
120Issue
10Pagination
1105 - 1117Publisher
American Physiological SocietyLocation
Bethesda, Md.Publisher DOI
Link to full text
ISSN
8750-7587eISSN
1522-1601Language
engPublication classification
C1.1 Refereed article in a scholarly journalCopyright notice
2016, American Physiological SocietyUsage metrics
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HippoYapexercisehypertrophyskeletal muscleAnimalsHumansMuscle, SkeletalPhysical Conditioning, AnimalProtein-Serine-Threonine KinasesSignal TransductionTranscription FactorsScience & TechnologyLife Sciences & BiomedicinePhysiologySport SciencesYES-ASSOCIATED PROTEINHYPOXIA-INDUCIBLE FACTORAMPK-MEDIATED REGULATIONGENOME-WIDE ASSOCIATIONSKELETAL-MUSCLE MASSPATHWAY EFFECTOR YAPCARDIAC STEM-CELLSTGF-BETASATELLITE CELLORGAN SIZE
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